Benzodiazepines: Miracle Drugs?
The first benzodiazepine – chlordiazepoxide – became available, from Hoffman-La Roche, in 1960, under the brand name Librium. It was soon followed by: diazepam (Valium) 1963; nitrazepam (Mogadon) and oxazepam (Serax) in 1965; temazepam (Restoril) 1969; clorazepate (Tranxene) 1972; flurazepam (Dalmane) 1973; clonazepam (Klonopin) 1975; lorazepam (Ativan) in 1977; and alprazolam (Xanax) in 1981; etc. Benzodiazepines are categorized as sedative/hypnotics, which means that they have a relaxing, generally pleasant, sleep-inducing effect, and were embraced promptly by psychiatry for the "treatment" of anxiety, tension, worry, sleeplessness, etc. In this respect, the benzodiazepines largely replaced the earlier barbiturates, which had received a great deal of negative publicity because of their much publicized role in lethal overdoses, both accidental and intentional. ...