SSRI's

Here’s an interesting story from Australia, recently back in the spotlight. From 1962 to 1979, psychiatrist Harry Bailey, MD, serving as chief psychiatrist at Chelmsford Private Hospital in New South Wales, practiced “deep sleep therapy”, which involved keeping people in barbiturate-induced comas for days or even weeks. Twenty-four of the individuals who received this “treatment” died while still in the hospital. Many more died or showed permanent brain damage after discharge. ...

On April 30, 2019, the very eminent and learned psychiatrist Ronald Pies, MD, published a piece in Psychiatric Times titled Debunking the Two Chemical Imbalance Myths, Again. Here’s the opening paragraph: "Like the legendary Count Dracula, who could be killed only by driving a stake through his heart, some myths seem almost immortal. For more than eight years now, I have tried to drive a stake through the heart of two myths regarding the so-called 'chemical imbalance theory'1-3—but with only limited success, as a recent piece in The New Yorker brought home to me.4" ...

On June 18, the British Medical Journal published an article by Christine Lu et al, titled Changes in antidepressant use by young people and suicidal behavior after FDA warnings and media coverage: quasi-experimental study. Here’s the conclusion paragraph from the abstract: "Safety warnings about antidepressants and widespread media coverage decreased antidepressant use, and there were simultaneous increases in suicide attempts among young people. It is essential to monitor and reduce possible unintended consequences of FDA warnings and media reporting." ...

There’s a new study in the January 2014 issue of the BMJ: Grigoriadis et al, Prenatal exposure to antidepressants and persistent pulmonary hypertension of the newborn: systematic review and meta-analysis. Thanks to Nanu Grewal for the link. PPHN is a relatively rare condition. The authors report that the estimated prevalence is about 1.9 per 1000 live births. The disease is essentially a failure of the newborn’s circulatory system to switch from oxygen supply via the placental blood, to oxygen supply via the baby’s own lungs. The condition is usually diagnosed at birth or shortly thereafter. Symptoms include: rapid and difficult breathing, fast heart rate, and blue skin color. PPHN is a serious condition. A 2010 article by Robin Steinhorn, MD, states: ...

There was an interesting article, Antidepressant regulations tightened following suicide, in the Copenhagen Post on January 7. Thanks to Mad in America for the link. It is reported that Danilo Terrida, aged 20, committed suicide in 2011 "…eleven days after he was prescribed antidepressants following an eight-minute-long conversation with a doctor." The doctor has been deemed responsible for the suicide by the National Agency for Patients' Rights and Complaints. According to its website: "The National Agency for Patients' Rights and Complaints functions as a single point of access for patients who wish to complain about the professional treatment in the Danish health service." ...

Last month (December 2013) the American Journal of Psychiatry published Antidepressant-Induced Liver Injury: A Review for Clinicians, by Voican C.S. et al. The study was a literature search from 1965 onwards. Here are the authors’ results: All antidepressants can induce hepatotoxicity, especially in elderly patients and those taking more than one drug Liver damage is generally unpredictable and unrelated to dose Liver damage can occur within a few days of initiation Antidepressant-induced liver failure can be life threatening Antidepressants with higher risk for liver failure include: iproniazid, nefazodone, phenelzine, imipramine, amitriptyline, duloxetine, bupropion, trazodone, tianeptine, and agomelatine Antidepressants with lower risk: citalopram, escitalopram, paroxetine, and fluvoxamine Although an infrequent event, antidepressant-induced liver injury may be irreversible   ...

On December 27, 2013, Connecticut State Police issued a 7,000-page, heavily redacted, report on the massacre that occurred at Sandy Hook Elementary School just over a year earlier (December 14, 2012). For the record, I have not read the 7,000-page report, but I have read the Wikipedia article Sandy Hook Elementary School shooting, last updated January 4, 2013, and several media reports on the matter, including reports from the New York Times, the Hartford Courant, and the Washington Post. ...

ANOTHER VIDEO FROM DR. LIEBERMAN On October 28, Jeffrey Lieberman, MD, President of the APA, made another video. This one is titled An Important Look at Mortality in Mental Illness: A Decade of Data on Psychotropic Drugs, and was made for Medscape. You can see the transcript at the same site. Medscape is a web resource for medical practitioners. The video is Dr. Lieberman’s commentary on an article that appeared in JAMA Psychiatry online on August 28: Comparative Mortality Risk in Adult Patients With Schizophrenia, Depression, Bipolar Disorder, Anxiety Disorders, and Attention-Deficit/Hyperactivity Disorder Participating in Psychopharmacology Clinical Trials, by Arif Khan, MD, et al. ...

SSRI’S AND SUICIDE Bob Fiddaman has a post up today called MHRA Consultant Calls for Antidepressant Use in Young. The article highlights some of the dangers associated with SSRI’s, and also describes some of the attempts to suppress or discount the significance of this information. Apparently in 2010, Swedish psychiatrist Göran Isacsson, MD, PhD, published a paper in Acta Psychiatrica Scandinavica. The piece was titled Antidepressant medication prevents suicide in depression, and reported that of a group of 1,077 depressed people who had committed suicide, only 15.2% had measurable amounts of antidepressants in the blood stream at the time of the suicide. ...

I’ve been reading another great book: Deadly Medicines and Organised Crime: How big pharma has corrupted healthcare, by Peter C. Gotzsche [Radcliffe Publishing, 2013]. The book is an exposé of pharma’s fraudulent research and marketing. The author is a Danish physician who has been involved in clinical trials of drugs, and in drug regulatory matters. He is a professor at the University of Copenhagen. He has published more than 50 papers, including papers in the BMJ, Lancet, JAMA, Annals of Internal Medicine, and the New England Journal of Medicine. ...